The feedback from this community outreach event in 2012 was very favorable. We plan to do it again, updating the community on research and treatment developments in several areas of neurology. The tentative date is Saturday, Noveember 2, 2013, beginning in the morning, again on UB’s North Campus. Topics will include stroke, memory disorders, multiple sclerosis, neuroimaging, and neuromuscular disorders.
The University at Buffalo’s Pediatric Multiple Sclerosis (MS) Center of Excellence will share in a $2.5 million National Multiple Sclerosis Society grant announced July 1.
UB MED Collaborations
A New Image of Multiple Sclerosis: UB Neurologists reveal key role of thalamus in the disease.
by Ellen Goldbaum
Neurologists at UB and their international collaborators have found that measuring atrophy of the thalamus using routine magnetic resonance imaging can be an important tool in detecting, evaluating, and predicting the course of multiple sclerosis.
Read it here: Dr. Zivadinov page 26
Dr. Robert Zivadinov and Dr. Ralph Benedict present findings about the important role of the Thalamus in MSPosted: March 24, 2013
Multiple Sclerosis research: The thalamus moves into the spotlight; Atrophy of the thalamus is an important predictor of clinically definite MS, study shows
By: Ellen Goldbaum
BUFFALO, N.Y. – A growing body of research by multiple sclerosis (MS) investigators at the University at Buffalo and international partners is providing powerful new evidence that the brain’s gray matter reflects important changes in the disease that could allow clinicians to diagnose earlier and to better monitor and predict how the disease will progress.
Over the past three years, the UB researchers and their partners around the world, supported by an active fellowship program at UB’s Buffalo Neuroimaging Analysis Center (BNAC), have published journal papers and given presentations demonstrating that the thalamus region, in particular, is key to a host of issues involving MS.
“The thalamus is providing us with a new window on MS,” says Robert Zivadinov, MD, PhD, UB professor of neurology, BNAC director and leader of the research team. “In our recent studies, we have used large datasets to investigate the evolution of atrophy of the thalamus and its association with clinical impairment in MS, starting with the earliest stages of the disease. The location of the thalamus in the brain, its unique function and its vulnerability to changes wrought by the disease make the thalamus a critical barometer of the damage that MS causes to the brain.”
Zivadinov and UB professor of neurology Ralph Benedict discuss the new research in a video at (http://youtu.be/QhsaHeBjZrA).
At the annual meeting of the American Academy of Neurology today, Zivadinov will discuss a study he performed in collaboration with colleagues from Charles University in Prague. The study found that atrophy of the thalamus, determined with MRI, can help identify which patients with clinically isolated syndrome (CIS), a patient’s first episode of MS, are at risk for developing clinically definite MS. Such a tool would be immensely helpful to clinicians, Zivadinov notes.
Media Advisory: State Sen. Grisanti and UB researchers advocate state funding for NYS Multiple Sclerosis Registry and Consortium
WATCH THE SUPPORT:
BUFFALO, N.Y. — New York State Senator Mark Grisanti will join multiple sclerosis researchers at the University at Buffalo and patients to advocate for funding by New York State to maintain and expand the New York State MS Registry and the New York State MS Consortium, directed by Bianca Weinstock-Guttman, MD, UB professor of neurology.
When: 1 p.m., March 15, 2013
Where: UB’s Clinical and Translational Science Center, 5 floor, above the Gates Vascular Institute, 875 Ellicott Street, Buffalo
Why: MS Awareness Week runs from March 11 to 17. The incidence of MS in Western New York is twice the national average. The disease costs New York State between $1.5 and $2.3 billion each year. Support for the registry and consortium of 15 MS centers across the state will facilitate NYS research on MS, boost physician knowledge about the disease and improve the quality of life for the 30,000 New York State residents with MS.
Speakers will include:
· State Sen. Mark Grisanti, a member of the MS Legislative Alliance for the New York State Senate, and whose family has been affected by MS
· Bianca Weinstock-Guttman, MD, UB professor of neurology in the School of Medicine and Biomedical Sciences, and director of the NYS MS Registry
· Murali Ramanathan, PhD, UB professor of pharmaceutical sciences in the School of Pharmacy and Pharmaceutical Sciences and MS researcher
· An MS patient
Press arrangements: Ellen Goldbaum of UB University Communications at 645-4605 and 771-9255 onsite.
The ANNETTE FUNICELLO RESEARCH FUND FOR NEUROLOGICAL DISEASES is calling Mousketeer and Beach Party fans to support multiple sclerosis research by world-renowned MS researcher, Robert Zivadinov of the University at Buffalo.
Your gift will be matched up to $7,500 by the Annette Funicello Research Fund.
Your support will allow Dr. Zivadinov and his team at the Buffalo Neuroimaging Analysis Center to learn more about Pediatric Multiple Sclerosis.
To make a gift, go to: http://www.giving.buffalo.edu/funicello
For information about MS research at University at Buffalo by Dr. Zivadinov, go to: www.BNAC.net
For information about the Annette Funicello Research Fund for Neurological Diseases, go to: https://calfund.org/page.aspx?pid=638
If you want to distribute flyers for this excellent cause: Funicello Fund Flyer
Buffalo study offers hope to multiple sclerosis patients
Scientists in recent years have found a way to infuse stem cells into the brains of animals to repair damage to the central nervous system, offering some of the most encouraging news yet for multiple sclerosis patients.
Now, a key $12.1 million study soon will be under way in Buffalo and two other upstate medical centers that will for the first time begin to test the procedure in people.
The hope is that the stem cells will generate new myelin, the fatty substance that surrounds nerves like the insulation on a wire. Myelin is damaged in MS, leading to weak or lost signals between nerves. Eventually, the painful disease spreads in a slow, unpredictable path toward paralysis.
by: Henry Davis
Read about it: www.buffalonews.com
The state of New York has committed to fund the project through the stem cell fund.
Dr. Bianca Weinstock-Guttman, MD, co-principal investigator on the study, is Professor of Neurology, State University of New York at Buffalo, and Director of the Baird MS Center at The Jacobs Neurological Institute. She is also the Director of the Pediatric MS Center of the Jacobs Neurological Institute, one of six centers of excellence established by the National MS Society. In addition, she also serves as Executive Director of the New York State Multiple Sclerosis Consortium (NYSMSC).
On the basis of results from the GALA study group, which included UB Dept. of Neurology faculty member Robert Zivadinov, MD, PhD, the FDA has approved three-times weekly glatiramer acetate (Copaxone) injections for relapsing-remitting multiple sclerosis. Prior approved dosing required daily injections. The study, which was conducted across 17 countries and involved more than 1400 patients, showed that the three-times weekly regimen is safe and effective, with the advantage of fewer injections. The GALA study was published in the June 2013 issue of Annals of Neurology. Dr. Zivadinov directs the Buffalo Neuroimaging Analysis Center which performed the MRI analysis for the trial.
For the study abstract, click here: http://onlinelibrary.wiley.com/doi/10.1002/ana.23938/abstract
An article that appeared in the journal Muscle & Nerve by Department of Neurology faculty Drs. Nicholas J. Silvestri and Gil I. Wolfe, on asymptomatic or mildly symptomatic elevated creatine kinase (CK) levels, a common presentation in neuromuscular practice, has been chosen by the American Association of Neuromuscular and Electrodiagnostic Medicine (AANEM) for reprint as a minimonograph. The AANEM has also made the review available for continuing medical education (CME) credits.
For the abstract, click on the link below:
Ed Fine, MD, Associate Professor of Neurology, is the recipient of the 2014 H. Richard Tyler Fellowship from the American Academy of Neurology (AAN). The fellowship encourages historical research related to neurology through the AAN Rare Books Collection housed at Washington University School of Medicine in St. Louis, MO.
The Dept. of Neurology had seven doctors named to the Castle Connolly Top Docs list for 2014 published in the January 2014 issue of Buffalo Spree magazine. The recognition follows screening by a physician-led team of researchers on both the national and regional levels. These are the physicians most highly regarded by their peers. Of note, four of seven neurologists and two of three child neurologists listed for the Buffalo region were members of our department. The physicians mentioned as Top Docs are:
Child Neurology: Thomas Langan, Arie Weinstock
Neurology: David Lichter, Robert Sawyer, Kinga Szigeti, Gil Wolfe
Ophthalmology: Norah Lincoff (neuro-ophthalmology)
For more information about our physicians, please check http://ubmd.com/practice-locations/practices/neurology.html
In a first-of-its-kind pilot study conducted by an international group of researchers, including UB Professor of Neurology Robert Zivadinov, MD, PhD, jugular venous reflux has been associated with white matter changes in the brain seen in patients with Alzheimer’s disease. White matter changes have long been associated with mild cognitive impairment and Alzheimer’s disease, and may relate to buildup of amyloid plaques, one of the key pathological features of Alzheimer’s disease. Although the study’s sample size is small, if validated through larger trials, it could potentially introduce new methods of diagnosing and managing patients with cognitive impairment. The study has been published in the Journal of Alzheimer’s Disease.\
The UB Dept. of Neurology stroke team, led by Dr. Robert Sawyer, Associate Professor of Neurology and Vice Chair of Clinical Services, helped Kaleida Health secure Primary Stroke Center status from Det Norske Veritas Healthcare (DNV) for a three year term through September 2016. DNV certification integrates requirements of the Center of Medicare/Medicaid Services and the American Stroke Association.
Dr. Christopher Deline, Assistant Professor of Neurology, who recently joined the department as a stroke provider, has won a Junior Investigator Travel Award from the American Heart Association. While training as a stroke fellow at Washington Univ. in St. Louis, Dr. Deline contributed to a study comparing acute mortality after ischemic stroke across industrialized countries. The study will be presented at the February 2014 International Stroke Conference in San Diego.
Thank you to all of the participants and our sponsors who helped make this year’s edition of Brains & Gains a big success. We hope the treatment updates and research study information provided was a value to the community. The faculty speakers have made their slides available, and they are attached. The slides are titled by topic and presenter. The Department of Neurology looks forward to presenting a 2014 edition next Fall!